New cholesterol derivatives via acylation of phosphonium salts

The interaction between phosphorus ylides and cholesteryl chloroformate has been investigated. The conditions and characteristics of this reaction in single-phase and two-phase systems using different bases have been established. A series of new acylated phosphorus ylides containing a holesteryl fragment has been obtained. The reaction proceeds under convenient conditions, starting from phosphonium salts, without the need to isolate the corresponding ylides in their individual state.